Neurology Newsfeed
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Neuroimaging-Use Trends in Nonacute Pediatric Headache Before and After Clinical Practice Parameters
Graf WD et al. - In the evaluation of patients who had nonacute pediatric headache and were referred to a child neurology clinic, neuroimaging-use rates remained stable during the past decade. An incr...Thu, 13 Nov 2008 00:00:00 EST
Intravenous Lidocaine in the Treatment of Refractory Headache: A Retrospective Case Series
Marmura M et al. - This study suggests benefit of lidocaine treatment and the need for further prospective analyses. The mechanism of lidocaine in treating headache is unknown. ......Thu, 13 Nov 2008 00:00:00 EST
Safety and Tolerability of Divalproex Sodium Extended-Release in the Prophylaxis of Migraine Headaches: Results of an Open-Label Extension Trial in Adolescents
Apostol G et al. - In this long-term open-label extension study, the safety profile of divalproex sodium extended-release in adolescents with migraine was consistent with that obse...Thu, 13 Nov 2008 00:00:00 EST
Optimizing prophylactic treatment of migraine: Subtypes and patient matching
Dib M - Advances in the understanding of the pathophysiology of migraine have resulted in important breakthroughs in treatment. Clinical research needs to be devoted to identifying...Thu, 13 Nov 2008 00:00:00 EST
Mandibular function, temporomandibular disorders, and headache in prematurely born children
Paulsson L et al. - Prematurely born children of 8 to 10 years of age did not differ from full-term born children when considering diagnoses according to RDC/TMD, signs, and sympto...Wed, 12 Nov 2008 00:00:00 EST
Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy
McDonald CR et al. - The results suggest that structural compromise to multiple fiber tracts is associated with memory and language impairments in patients with temporal lobe epile...Fri, 14 Nov 2008 00:00:00 EST
Predictors of surgical outcome and pathologic considerations in focal cortical dysplasia
Kim DW et al. - Their study shows that there is a strong tendency for patients with severe pathologic features to have MRI abnormalities, and patients with incomplete resection, mi...Fri, 14 Nov 2008 00:00:00 EST
Doublecortin expression in the normal and epileptic adult human brain
Liu YWJ et al. - This study has identified, for the first time, a novel population of Dcx-positive cells in the adult human temporal cortex that can be upregulated by epilepsy and ...Thu, 13 Nov 2008 00:00:00 EST
Blockade of Estrogen Receptor Signaling Inhibits Growth and Migration of Medulloblastoma
Belcher SM et al. - Medulloblastoma is the most common malignant brain tumors in children. These invasive neuroectodermal tumors arise from cerebellar granule cell-like precursors....Fri, 14 Nov 2008 00:00:00 EST
Orexin-A hyperphagia: Hindbrain participation in consummatory feeding responses
Baird JP et al. - Orexin-A (ORXA) is an orexigenic neuropeptide produced the lateral hypothalamus that increases food intake when injected into the brain ventricles or forebrain nuclei. ......Fri, 14 Nov 2008 00:00:00 EST
CT-colonography in acromegaly
Resmini E et al. - CT-colonography has the potential ability to replace traditional colonoscopy in acromegalic patients. CT colonography could be used as screening modality for colon cancer...Thu, 13 Nov 2008 00:00:00 EST
Botulinum toxin: From life-threatening disease to novel medical therapy
Mahajan ST et al. - Botulinum toxin A is the newest therapy for the treatment of a variety of medical disorders caused by abnormalities of muscle activity. After successful use in other med...Mon, 17 Nov 2008 00:00:00 EST
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol
Martin GE et al. - The data indicate that the [beta]4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alc...Mon, 17 Nov 2008 00:00:00 EST
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine
Bilbao A et al. - Authors found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regi...Mon, 17 Nov 2008 00:00:00 EST
MTHFR 677C - T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val - Met
Roffman JL et al. - The findings are consistent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, and suggest that in schizophrenia patients, the ...Mon, 17 Nov 2008 00:00:00 EST
New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
Zecca L et al. - The synthesis of neuromelanins in the various regions of the human brain is an important protective process because the melanic component is generated through the removal o...Mon, 17 Nov 2008 00:00:00 EST
Dispensing errors have been reported between TOPAMAX® (topiramate) Tablets and TOPROL-XL® (metoprolol succinate) extended-release Tablets.
Please be sure to check your tablets to ensure you are taking the right medicine.
*TOPROL-XL is a registered trademark of the AstraZeneca group of companies.
TOPAMAX Tablets and TOPAMAX Sprinkle Capsules are indicated for adults for the prophylaxis of migraine headache. The usefulness of TOPAMAX in the acute treatment of migraine headache has not been studied.
TOPAMAX is contraindicated in patients with a history of hypersensitivity to any component of this product.
IMPORTANT SAFETY INFORMATION
TOPAMAX has been associated with serious adverse events, including:
- Hyperchloremic, non-anion gap metabolic acidosis - lowering of bicarbonate levels in the blood. Measurement of baseline and periodic serum bicarbonate is recommended.
- Acute myopia and secondary angle-closure glaucoma - patients should be cautioned to seek medical attention if they experience blurred vision or ocular pain.
- Oligohidrosis and hyperthermia - decreased sweating and increased body temperature, especially in hot weather. The majority of reports have been in children.
- Cognitive/psychiatric side effects including cognitive dysfunction, psychiatric/behavioral disturbances, including suicidal thoughts or behavior, and somnolence and fatigue.
Most common adverse events associated with TOPAMAX 100 mg vs placebo were: paresthesia, 51% vs 6%; anorexia,* 15% vs 6%; fatigue, 15% vs 11%; nausea, 13% vs 8%; diarrhea, 11% vs 4%; weight decrease, 9% vs 1%; taste alteration, 8% vs 1%.
The possibility of decreased contraceptive efficacy and increased breakthrough bleeding should be considered in patients taking combination oral contraceptive products with TOPAMAX.
Patients should be instructed to maintain an adequate fluid intake in order to minimize the risk of renal stone formation.
*Anorexia is defined as loss of appetite
Please see full U.S. Prescribing Information
